ApoE, Energy, and Synaptic V-ATPase
Humans possess three major isoforms of the apolipoprotein E (ApoE) gene coded by three alleles—ε2, ε3, and ε4—that have differentiated risk factors to late-onset Alzheimer’s disease (AD). ApoE4 is currently recognized as the most potent genetic risk factor for AD and ApoE2 as a neuroprotective variant. While there exists an abundance of research demonstrating the neurotoxic impact caused by ApoE4, far less is known about the mechanisms by which ApoE2 delegates neuroprotection.
To address this research gap, this project is attempted to identify the molecular bases that distinguish an ApoE2 brain from ApoE3 and ApoE4 brains and that could contribute to the neuroprotective nature of ApoE2.
Department of Pharmacology & Toxicology
1251 Wescoe Hall Drive
Malott Hall, Room 5064
University of Kansas
Lawrence, KS 66045